Mouse Gene Arg1 (ENSMUST00000020161.10) from GENCODE VM35
Description: Mus musculus arginase, liver (Arg1), mRNA. (from RefSeq NM_007482) Gencode Transcript: ENSMUST00000020161.10 Gencode Gene: ENSMUSG00000019987.10 Transcript (Including UTRs) Position:mm39 chr10:24,791,119-24,803,382Size:12,264Total Exon Count:8Strand:- Coding Region Position:mm39 chr10:24,791,508-24,803,266Size:11,759Coding Exon Count:8
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Sequence and Links to Tools and Databases
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Comments and Description Text from UniProtKB
ID: ARGI1_MOUSE DESCRIPTION: RecName: Full=Arginase-1; EC=3.5.3.1; AltName: Full=Liver-type arginase; AltName: Full=Type I arginase; CATALYTIC ACTIVITY: L-arginine + H(2)O = L-ornithine + urea. COFACTOR: Binds 2 manganese ions per subunit (By similarity). PATHWAY: Nitrogen metabolism; urea cycle; L-ornithine and urea from L-arginine: step 1/1. SUBUNIT: hom*otrimer (By similarity). SUBCELLULAR LOCATION: Cytoplasm. SIMILARITY: Belongs to the arginase family. SEQUENCE CAUTION: Sequence=BAE28901.1; Type=Erroneous initiation; |
Primer design for this transcript
Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA. Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence. To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3 |
Comparative Toxicogenomics Database (CTD)
The following chemicals interact with this gene
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mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have. |
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR014033 - Arginase IPR006035 - Ureohydrolase IPR023696 - Ureohydrolase_domain IPR020855 - Ureohydrolase_Mn_BS Pfam Domains: ModBase Predicted Comparative 3D Structure on Q61176
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
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Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0004053 arginase activity GO:0016787 hydrolase activity GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines GO:0030145 manganese ion binding GO:0046872 metal ion binding Biological Process: Cellular Component: |
Descriptions from all associated GenBank mRNAs
U88541 - Mus musculus blastocyst arginase hom*olog mRNA, 3'UTR sequence. AK149471 - Mus musculus adult male liver tumor cDNA, RIKEN full-length enriched library, clone:C730019N20 product:arginase 1, liver, full insert sequence. BC013341 - Mus musculus arginase, liver, mRNA (cDNA clone MGC:13983 IMAGE:4163626), complete cds. AK171417 - Mus musculus B6-derived CD11 +ve dendritic cells cDNA, RIKEN full-length enriched library, clone:F730211I08 product:arginase 1, liver, full insert sequence. BC050005 - Mus musculus arginase, liver, mRNA (cDNA clone MGC:58976 IMAGE:3990246), complete cds. U51805 - Mus musculus arginase mRNA, complete cds. CT010173 - Mus musculus full open reading frame cDNA clone RZPDo836B0650D for gene Arg1, Arginase 1, liver; complete cds, incl. stopcodon. |
Biochemical and Signaling Pathways
BioCyc Knowledge Library ARG-PRO-PWY - arginine degradation VI (arginase 2 pathway) ARGASEDEG-PWY - arginine degradation I (arginase pathway) CITRULBIO-PWY - citrulline biosynthesis PWY-4984 - urea cycle PWY-5004 - superpathway of citrulline metabolism Reactome (by CSHL, EBI, and GO) Protein Q61176 (Reactome details) participates in the following event(s): R-MMU-6798749 Exocytosis of specific granule lumen proteins |
Alternate Gene Symbols: ARGI1_MOUSE, ENSMUST00000020161.1, ENSMUST00000020161.2, ENSMUST00000020161.3, ENSMUST00000020161.4, ENSMUST00000020161.5, ENSMUST00000020161.6, ENSMUST00000020161.7, ENSMUST00000020161.8, ENSMUST00000020161.9, NM_007482, Q3TB74, Q3UEL0, Q4FK78, Q61176, Q80VI4, uc007erg.1, uc007erg.2, uc007erg.3, uc007erg.4 UCSC ID: ENSMUST00000020161.10 RefSeq Accession: NM_007482 Protein: Q61176 (aka ARGI1_MOUSE or ARGI_MOUSE) |